Depot Inn & Suites is themed after an 1800's railroad depot and is decorated with many historic railroad artifacts making the hotel a small railroad museum in and of itself. Mid West's Finest, Unique and Upscale Lodging Experience! 26 Standard Rooms, 4 Themed Luxury Suites. Guests can start their mornings out with complimentary continental breakfasts and enjoy complimentary coffee and tea around the clock. Indoor pool, patio with grills, business center, meeting room, in-house laundry, playground, professional putting green, bicycles and Golf Cart for guest use. All rooms include refrigerator, microwave, hairdryer, iron/board, cable TV. Themed Suites have hot tubs. Heavily decorated with antiques and railroad memorabilia. Train-watching facility within walking distance. Free Shuttle service to Amtrak depot and Kirksville Regional Airport. Three Free Tesla Charging station onsite. Nearby 18 hole golf course. Bus tours of Amish country, Walt Disney's Hometown -- Marceline, Missouri, Mark Twain's Hometown, Hannibal, Missouri. Independently owned and operated.

Situated in La Plata, Depot Inn & Suites offers a garden and BBQ facilities. Featuring a restaurant, the property also has free bikes, as well as an indoor pool and a fitness centre. The accommodation features a 24-hour front desk, airport transfers, a shared lounge and free WiFi throughout the property.

All air-conditioned units at the hotel come with a fridge, a microwave, a coffee machine, a shower, free toiletries, a flat-screen TV with cable channels and DVD player. The rooms have a private bathroom, a hairdryer and bed linen.

Depot Inn & Suites offers a children's playground. You can play billiards at the accommodation, and the area is popular for fishing and cycling.

A business centre and vending machines with snacks and drinks are available on site at Depot Inn & Suites.

The nearest airport is Kirksville Regional Airport, 9 km from the hotel.